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High-Protein Ground Beef & Brussels Sprouts Skillet Recipe

Allan
his High-Protein Ground Beef & Brussels Sprouts Skillet (Easy One-Pan Meal!) is the perfect combination of simplicity, flavor, and nutrition. Made in just one skillet, it features caramelized Brussels sprouts, rich savory beef, and bold seasonings that create a satisfying meal without the fuss. With over 33g of protein per serving, it’s a healthy, delicious, and family-friendly recipe you'll want to make again and again.
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Prep Time 10 minutes
Cook Time 15 minutes
Total Time 25 minutes
Course Dinner
Cuisine American, High Protein
Servings 4
Calories 292 kcal

Ingredients
  

Main Ingredients

  • 1 lb 450g extra-lean ground beef (93%)
  • 1 lb Brussels sprouts halved
  • 1 medium onion diced
  • 3 garlic cloves minced
  • 1 tbsp olive oil

Seasonings

  • ½ tsp salt adjust to taste
  • ½ tsp black pepper
  • 1 tsp smoked paprika or regular
  • 1 tsp garlic powder
  • ½ tsp onion powder
  • ½ tsp red chili flakes optional

Flavor Boosters

  • 2 tbsp low-sodium soy sauce or coconut aminos
  • ½ tsp Dijon mustard optional but recommended

Instructions
 

  • Trim the Brussels sprouts, remove any damaged leaves, and slice each sprout in half.
  • Toss the halved sprouts in a bowl with olive oil, salt, pepper, and smoked paprika until coated evenly.
  • Heat a large cast-iron skillet over medium-high heat and place the Brussels sprouts cut-side down in a single layer. Let them sear undisturbed for 3–4 minutes until golden brown.
  • Push the Brussels sprouts to one side of the skillet to make space for the ground beef.
  • Add the ground beef to the empty side of the skillet and break it apart with a wooden spoon. Cook until the beef is browned and no longer pink.
  • Add the diced onion and minced garlic to the skillet and stir to combine, cooking until the onion softens and becomes fragrant.
  • Sprinkle garlic powder, onion powder, smoked paprika, black pepper, and chili flakes (optional) over the mixture. Stir well to coat the beef and sprouts in the seasoning.
  • Add the soy sauce and Dijon mustard to the skillet, stirring until everything is fully combined and coated in the savory glaze.
  • Continue cooking for another 3 minutes to allow the flavors to blend and the Brussels sprouts to finish cooking.
  • Taste and adjust seasoning as needed, adding extra salt, pepper, paprika, or lemon juice if desired.
  • Serve warm as a one-pan meal or pair with rice, quinoa, eggs, or your favorite sides.
  • Store leftovers in an airtight container in the fridge for up to 4 days or freeze for up to 3 months.