Bring a large pot of salted water to a boil and cook the high-protein rotini until al dente according to the package directions. Drain, rinse briefly under cool water, and allow the pasta to cool completely.
Heat a large skillet over medium-high heat and cook the lean ground turkey until browned, breaking it into small crumbles. Stir in the chili powder, smoked paprika, cumin, garlic powder, onion powder, turmeric, oregano, salt, and black pepper, then cook for another 2–3 minutes until fragrant. Allow the turkey to cool.
In a medium bowl, whisk together the Greek yogurt, avocado oil mayonnaise, lime juice, garlic powder, smoked paprika, onion powder, salt, and black pepper until smooth and creamy.
Wash and dry the vegetables thoroughly. Halve the cherry tomatoes, dice the bell pepper, finely chop the red onion, chop the romaine lettuce, dice the avocado, and chop the fresh cilantro.
In a large mixing bowl, combine the cooled pasta, seasoned turkey, tomatoes, bell pepper, onion, cheddar cheese, and cilantro.
Pour most of the creamy dressing over the salad and gently toss until everything is evenly coated. Add additional dressing as needed until the desired consistency is reached.
Fold in the chopped romaine lettuce and diced avocado just before serving to preserve their texture, then refrigerate the salad for at least 30 minutes so the flavors can blend.
Give the salad one gentle stir, garnish with extra cilantro, avocado, pumpkin seeds, lime wedges, or your favorite toppings, and serve chilled.