Nothing beats a warm casserole when you’re looking for an easy, comforting dinner that also delivers plenty of protein. These high protein casserole recipes combine lean meats, vegetables, wholesome ingredients, and plenty of flavor into complete meals the whole family will enjoy. They’re ideal for busy weeknights, meal prep, potlucks, or make-ahead dinners.

From cheesy chicken casseroles to hearty beef bakes, turkey favorites, seafood dishes, and vegetarian options, this collection offers delicious casseroles that are filling, simple to prepare, and packed with protein.

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1. Cheesy Chicken Broccoli Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds boneless skinless chicken breasts, cooked and shredded
• 4 cups broccoli florets
• 1 cup plain Greek yogurt
• 1 cup shredded cheddar cheese
• ½ cup grated Parmesan cheese
• 2 eggs
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Steam the broccoli for 3 minutes.
3. Mix chicken, broccoli, Greek yogurt, eggs, garlic powder, onion powder, salt, and pepper.
4. Stir in half of the cheddar cheese.
5. Transfer to a greased baking dish.
6. Top with remaining cheddar and Parmesan.
7. Bake for 35 minutes until golden and bubbly.

Nutrition (Per Serving)

• Calories: 392
• Protein: 43g
• Carbs: 8g
• Fat: 20g

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2. Lean Beef Taco Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds lean ground beef
• 1 cup black beans, rinsed
• 1 cup corn kernels
• 1½ cups salsa
• 1 cup shredded cheddar cheese
• 1 teaspoon taco seasoning
• 2 eggs
• ½ cup plain Greek yogurt

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the ground beef and drain excess fat.
3. Stir in taco seasoning, black beans, corn, and salsa.
4. Mix in Greek yogurt and eggs.
5. Transfer to a baking dish.
6. Sprinkle with cheddar cheese.
7. Bake for 30–35 minutes.

Nutrition (Per Serving)

• Calories: 425
• Protein: 39g
• Carbs: 15g
• Fat: 24g

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3. Buffalo Chicken Cauliflower Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked shredded chicken
• 1 medium cauliflower, cut into florets
• ½ cup buffalo sauce
• 1 cup plain Greek yogurt
• 1 cup shredded mozzarella cheese
• ½ cup crumbled blue cheese
• 1 teaspoon garlic powder
• Salt and black pepper

Instructions

1. Heat oven to 375°F (190°C).
2. Steam cauliflower for 5 minutes.
3. Mix chicken, cauliflower, buffalo sauce, Greek yogurt, garlic powder, salt, and pepper.
4. Spread into a baking dish.
5. Top with mozzarella and blue cheese.
6. Bake for 35 minutes until hot and bubbly.

Nutrition (Per Serving)

• Calories: 401
• Protein: 44g
• Carbs: 9g
• Fat: 21g

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4. Turkey Spinach Egg Casserole

Prep Time: 15 minutes

Cook Time: 40 minutes

Total Time: 55 minutes

Servings: 6

Ingredients

• 1 pound lean ground turkey
• 10 large eggs
• 3 cups baby spinach
• 1 cup cottage cheese
• 1 cup shredded mozzarella cheese
• 1 teaspoon garlic powder
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the turkey in a skillet.
3. Whisk eggs with cottage cheese, garlic powder, salt, and pepper.
4. Stir in spinach and cooked turkey.
5. Pour into a greased baking dish.
6. Top with mozzarella.
7. Bake for 40 minutes.

Nutrition (Per Serving)

• Calories: 355
• Protein: 38g
• Carbs: 5g
• Fat: 20g

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5. Chicken Alfredo Zucchini Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked chicken breast, shredded
• 3 zucchini, sliced
• 1 cup light Alfredo sauce
• 1 cup shredded mozzarella cheese
• ½ cup grated Parmesan cheese
• 1 teaspoon Italian seasoning
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Layer zucchini and chicken in a baking dish.
3. Pour Alfredo sauce evenly over the top.
4. Sprinkle with mozzarella, Parmesan, and Italian seasoning.
5. Bake for 35 minutes until bubbly and lightly browned.

Nutrition (Per Serving)

• Calories: 396
• Protein: 42g
• Carbs: 8g
• Fat: 21g

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6. High Protein Tuna Noodle Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 3 cans tuna in water, drained
• 8 ounces high-protein pasta, cooked
• 1 cup plain Greek yogurt
• 1 cup frozen peas
• 1 cup shredded cheddar cheese
• ½ cup grated Parmesan cheese
• 1 teaspoon garlic powder
• Salt and black pepper

Instructions

1. Heat oven to 375°F (190°C).
2. Mix tuna, cooked pasta, Greek yogurt, peas, garlic powder, salt, and pepper.
3. Transfer to a baking dish.
4. Top with cheddar and Parmesan.
5. Bake for 35 minutes until golden.

Nutrition (Per Serving)

• Calories: 418
• Protein: 40g
• Carbs: 22g
• Fat: 18g

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7. Ground Turkey Enchilada Casserole

Prep Time: 20 minutes

Cook Time: 35 minutes

Total Time: 55 minutes

Servings: 6

Ingredients

• 2 pounds lean ground turkey
• 1½ cups enchilada sauce
• 8 corn tortillas, cut into strips
• 1 cup black beans
• 1 cup shredded Mexican cheese blend
• 1 teaspoon cumin
• 1 teaspoon chili powder

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the turkey with cumin and chili powder.
3. Layer tortillas, turkey, beans, and enchilada sauce in a baking dish.
4. Top with cheese.
5. Bake for 35 minutes until bubbly.

Nutrition (Per Serving)

• Calories: 432
• Protein: 41g
• Carbs: 21g
• Fat: 20g

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8. Ham and Egg Breakfast-for-Dinner Casserole

Prep Time: 15 minutes

Cook Time: 40 minutes

Total Time: 55 minutes

Servings: 6

Ingredients

• 2 cups diced lean ham
• 10 large eggs
• 1 cup cottage cheese
• 1 cup shredded cheddar cheese
• 1 bell pepper, diced
• 2 green onions, sliced
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Whisk eggs with cottage cheese, salt, and pepper.
3. Stir in ham, bell pepper, green onions, and half the cheddar.
4. Pour into a greased baking dish.
5. Top with remaining cheddar.
6. Bake for 40 minutes until set.

Nutrition (Per Serving)

• Calories: 366
• Protein: 36g
• Carbs: 6g
• Fat: 21g

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9. Italian Chicken Parmesan Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked chicken breast, cubed
• 2 cups marinara sauce
• 1½ cups shredded mozzarella cheese
• ½ cup grated Parmesan cheese
• 1 cup high-protein pasta, cooked
• 1 teaspoon Italian seasoning
• ½ teaspoon garlic powder
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Combine chicken, pasta, marinara sauce, garlic powder, Italian seasoning, salt, and pepper.
3. Transfer to a greased baking dish.
4. Sprinkle with mozzarella and Parmesan.
5. Bake for 35 minutes until the cheese is melted and bubbly.
6. Let rest for 5 minutes before serving.

Nutrition (Per Serving)

• Calories: 421
• Protein: 43g
• Carbs: 19g
• Fat: 20g

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10. Philly Cheesesteak Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds lean ground beef
• 2 bell peppers, sliced
• 1 onion, sliced
• 8 ounces mushrooms, sliced
• 1½ cups shredded provolone cheese
• ½ cup cream cheese
• 1 teaspoon garlic powder
• Salt and black pepper

Instructions

1. Heat oven to 375°F (190°C).
2. Brown the beef and drain excess fat.
3. Cook the peppers, onion, and mushrooms until softened.
4. Stir in cream cheese until smooth.
5. Transfer everything to a baking dish.
6. Top with provolone cheese and bake for 30–35 minutes.

Nutrition (Per Serving)

• Calories: 438
• Protein: 40g
• Carbs: 8g
• Fat: 27g

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11. Shrimp and Broccoli Rice Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds large shrimp, peeled
• 2 cups cooked brown rice
• 3 cups broccoli florets
• 1 cup plain Greek yogurt
• 1 cup shredded mozzarella cheese
• 2 garlic cloves, minced
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Steam broccoli for 3 minutes.
3. Combine shrimp, rice, broccoli, Greek yogurt, garlic, salt, and pepper.
4. Transfer to a baking dish.
5. Sprinkle mozzarella over the top.
6. Bake for 30–35 minutes until the shrimp are cooked through.

Nutrition (Per Serving)

• Calories: 396
• Protein: 39g
• Carbs: 20g
• Fat: 16g

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12. Mexican Chicken Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked shredded chicken
• 1 cup black beans
• 1 cup corn kernels
• 1½ cups salsa
• 1 cup shredded Mexican cheese blend
• ½ cup plain Greek yogurt
• 1 teaspoon cumin
• 1 teaspoon chili powder

Instructions

1. Heat oven to 375°F (190°C).
2. Mix chicken, black beans, corn, salsa, Greek yogurt, cumin, and chili powder.
3. Spread into a greased baking dish.
4. Top with shredded cheese.
5. Bake for 35 minutes until hot and bubbly.
6. Cool slightly before serving.

Nutrition (Per Serving)

• Calories: 417
• Protein: 42g
• Carbs: 16g
• Fat: 19g

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13. Cottage Cheese Lasagna Bake

Prep Time: 20 minutes

Cook Time: 45 minutes

Total Time: 1 hour 5 minutes

Servings: 6

Ingredients

• 1½ pounds lean ground turkey
• 8 lasagna noodles, cooked
• 2 cups low-fat cottage cheese
• 2 cups marinara sauce
• 1½ cups shredded mozzarella cheese
• ½ cup grated Parmesan cheese
• 1 teaspoon Italian seasoning

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the turkey and season with Italian seasoning.
3. Layer noodles, turkey, marinara, cottage cheese, and mozzarella in a baking dish.
4. Repeat the layers.
5. Top with Parmesan cheese.
6. Bake for 45 minutes until golden and bubbly.

Nutrition (Per Serving)

• Calories: 446
• Protein: 41g
• Carbs: 24g
• Fat: 20g

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14. Chicken Bacon Ranch Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked chicken breast, cubed
• 6 slices turkey bacon, cooked and chopped
• 1 cup plain Greek yogurt
• 2 tablespoons ranch seasoning
• 1½ cups shredded cheddar cheese
• 2 cups broccoli florets
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Steam the broccoli for 3 minutes.
3. Mix chicken, broccoli, turkey bacon, Greek yogurt, ranch seasoning, salt, and pepper.
4. Spread into a baking dish.
5. Top with cheddar cheese.
6. Bake for 35 minutes until golden.

Nutrition (Per Serving)

• Calories: 432
• Protein: 44g
• Carbs: 8g
• Fat: 23g

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15. Mediterranean Turkey Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds lean ground turkey
• 2 zucchini, diced
• 1 cup cherry tomatoes, halved
• ½ cup sliced Kalamata olives
• 1 cup crumbled feta cheese
• 1 teaspoon oregano
• 2 garlic cloves, minced

Instructions

1. Heat oven to 375°F (190°C).
2. Brown the turkey with garlic.
3. Stir in zucchini, tomatoes, olives, and oregano.
4. Transfer to a baking dish.
5. Top with feta cheese.
6. Bake for 35 minutes until hot.

Nutrition (Per Serving)

• Calories: 398
• Protein: 40g
• Carbs: 8g
• Fat: 22g

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16. Beef and Mushroom Protein Bake

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds lean ground beef
• 8 ounces mushrooms, sliced
• 1 onion, diced
• 1 cup cottage cheese
• 1½ cups shredded mozzarella cheese
• 1 teaspoon Worcestershire sauce
• 1 teaspoon garlic powder
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the beef with onion and mushrooms.
3. Stir in Worcestershire sauce, garlic powder, salt, and pepper.
4. Fold in cottage cheese.
5. Transfer to a baking dish.
6. Top with mozzarella and bake for 35 minutes.

Nutrition (Per Serving)

• Calories: 441
• Protein: 42g
• Carbs: 7g
• Fat: 27g

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17. Chicken Fajita Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds boneless skinless chicken breasts, sliced
• 2 bell peppers, sliced
• 1 onion, sliced
• 1 cup plain Greek yogurt
• 1½ cups shredded Monterey Jack cheese
• 1 teaspoon chili powder
• 1 teaspoon cumin
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Toss the chicken with chili powder, cumin, salt, and pepper.
3. Combine the chicken, peppers, onion, and Greek yogurt in a large bowl.
4. Transfer to a greased baking dish.
5. Top with Monterey Jack cheese.
6. Bake for 35 minutes until the chicken is fully cooked and the cheese is bubbly.

Nutrition (Per Serving)

• Calories: 415
• Protein: 43g
• Carbs: 8g
• Fat: 21g

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18. Salmon Spinach Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds cooked salmon, flaked
• 4 cups baby spinach
• 1 cup cottage cheese
• 1 cup shredded mozzarella cheese
• 2 eggs
• 1 teaspoon garlic powder
• ½ teaspoon dried dill
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Mix the salmon, spinach, cottage cheese, eggs, garlic powder, dill, salt, and pepper.
3. Spread the mixture into a greased baking dish.
4. Sprinkle mozzarella over the top.
5. Bake for 35 minutes until set and lightly browned.
6. Let cool for 5 minutes before serving.

Nutrition (Per Serving)

• Calories: 402
• Protein: 41g
• Carbs: 5g
• Fat: 23g

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19. Chicken and Quinoa Casserole

Prep Time: 15 minutes

Cook Time: 40 minutes

Total Time: 55 minutes

Servings: 6

Ingredients

• 2 pounds cooked chicken breast, shredded
• 2 cups cooked quinoa
• 2 cups broccoli florets
• 1 cup plain Greek yogurt
• 1 cup shredded cheddar cheese
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Steam the broccoli for 3 minutes.
3. Combine chicken, quinoa, broccoli, Greek yogurt, garlic powder, onion powder, salt, and pepper.
4. Transfer to a baking dish.
5. Top with cheddar cheese.
6. Bake for 40 minutes until hot and golden.

Nutrition (Per Serving)

• Calories: 432
• Protein: 43g
• Carbs: 18g
• Fat: 20g

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20. High Protein Cheeseburger Casserole

Prep Time: 15 minutes

Cook Time: 35 minutes

Total Time: 50 minutes

Servings: 6

Ingredients

• 2 pounds lean ground beef
• 1 cup low-fat cottage cheese
• 1½ cups shredded cheddar cheese
• 1 cup diced tomatoes
• ½ cup diced onion
• 2 tablespoons sugar-free ketchup
• 1 teaspoon yellow mustard
• Salt and black pepper

Instructions

1. Preheat oven to 375°F (190°C).
2. Brown the ground beef with the onion and drain any excess fat.
3. Stir in the tomatoes, ketchup, mustard, cottage cheese, salt, and pepper.
4. Transfer the mixture to a greased baking dish.
5. Sprinkle cheddar cheese over the top.
6. Bake for 35 minutes until the cheese is melted and bubbling.

Nutrition (Per Serving)

• Calories: 446
• Protein: 42g
• Carbs: 7g
• Fat: 28g

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Conclusion

These easy high protein casserole dinner recipes make comfort food both wholesome and satisfying. Packed with lean proteins, nutritious ingredients, and rich flavors, they’re perfect for meal prep, family dinners, and busy weeknights when you need an easy oven-baked meal. Save this collection for delicious casseroles that are filling, protein-packed, and guaranteed to become regular favorites in your dinner rotation.